- Cassiopeia is a deadly creature bent on manipulating others to her sinister will. Youngest and most beautiful daughter of the noble Du Couteau family of Noxus, she ventured deep into the crypts beneath Shurima in search of ancient power. There, she was bitten by a gruesome tomb guardian, whose venom transformed her into a viper-like predator. Cunning and agile, Cassiopeia now slithers under the veil of night, petrifying her enemies with her baleful gaze.
- Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
- Lead your enemy when targeting with Noxious Blast to ensure the hit.
- Be wary of Cassiopeia's damage potential with Twin Fang when she has you poisoned.
- Turn away from Cassiopeia when she is casting Petrifying Gaze to get slowed instead of stunned.